Members of the Hanson Lab have co-authored a new Proceedings of the National Academy of Sciencespublication on work towards improving photosynthesis. Kevin Hines (Ph.D. ’19), a recent Hanson Lab alum, and Vishal Chaudhari, postdoctoral associate in Hanson’s lab, were co-first authors. Kristen Edgeworth, a former NSF REU student, and Thomas Owens, Section of Plant Biology, joined Hines and Chaudhari, and Hanson in the work.
The paper outlines progress towards the goal of concentrating carbon dioxide (CO2) in the chloroplast of plants. A feat that would improve photosynthesis by enhancing the efficiency of carbon fixation. The removal of carbonic anhydrase is an important step in the overall process. Carbonic anhydrase is naturally occurring in plants and works to balance levels of CO2 and bicarbonate.
The Cornell Chronicle has published an article that describes this work in more detail.
This manuscript takes a look at 4,790 circulating plasma proteins from 20 ME/CFS women compared to 20 healthy women, over an unprecedented range, for ME/CFS, of 9 orders of magnitude.
Pathway analysis uncovered disrupted cell-to-cell communication, specifically in the ephrin-Eph signaling pathway. This pathway is crucial for many aspects of our body’s homeostasis, including development, physiology, and disease regulation.
Additionally, the paper outlines promising results for the development of a diagnostic test using protein ratios.
First author, Arnaud Germain, PhD, outlines these findings in a video abstract below.
Hanson Lab Postdoctoral Research Associate, Myat Lin, is first author on a Nature Plantspublication that outlines new advances on the use of Escherichia coli for improving photosynthesis. The publication highlights key work in providing a microbial platform for the continued enhancement of Rubisco enzyme kinetics. Vishal Chaudhari and Maureen Hanson from our lab and William Stone ’18 contributed to this work.
The Cornell Chronicle has published an article on this work. The Nature Plants publication has limited access, but the Cornell Chronicle article is freely available.
Collaboration between the Hanson Lab and researchers at the Lancaster Environment Centre, Lancaster University, produced a February 2020 publication in Plant Physiology. The publication outlines progress towards engineering a cyanobacteria CO2 concentrating mechanism in plants, an achievement that has the potential to increase crop production by improving photosynthesis. Particularly, the paper demonstrates the ability to form a hybrid Rubisco enzyme composed of a plant (tobacco) small subunit and a cyanobacteria (Synechococcus elongatus) large subunit. Check out the publication to take a closer look into this fascinating research.
Cyanobacterial Rubisco introduced into transplastomic tobacco plants was reported in Nature in September, 2014. Two different tobacco genotypes that fix all carbon with a Rubisco enzyme derived from cyanobacteria have been produced following engineering the chloroplast genome by two different strategies. Producing these plants are an important step needed to introduce the entire cyanobacterial CO2-concentration mechanism into crop plants for improved photosynthesis and crop yield.